Hypomethylation of NOX4 has been observed in various cancer types, including breast cancer, lung squamous cell carcinoma, bladder cancer, lung adenocarcinoma, prostate cancer, endometrial cancer, gastric cancer, thyroid cancer, and gallbladder cancer, suggesting that epigenetic modifications may contribute to its dysregulation in cancer. The gene discussed is NOX4; the disease is Familial prostate cancer.