PNIPAAm and functional paringmotif conjugates, integrating a human epidermal growth factor receptor-2(HER2) targeting peptide (CGKGGMSRTMSG), were reportedas potential temperature-responsive materials in tumor therapy toprevent cancer cell proliferation.119 Investigationswere also led on monitoring in tumor therapy.120 Peptides with responsive and penetrating motifs, as wellas a signal molecule, were conjugated to the thermosensitive PNIPAAm.Due to their phase transition, the conjugates can form nanoaggregatesin cells. This evidence concerns the gene ERBB2 and neoplasm.