We identified immunostimulators (VTCN1, TGFB1, CDC244, LAG3, PDCD1, TIGIT, IDO1, CD274, ADORA2A, KDR) and immunoinhibitors (TNFSF13, TNFSF4, KLRC1, TNFRSF25, IL2RA, CXCR4, ENTPD1, ULBP1, RAET1E, KLRK1, CD276, TMIGD2, IL6, CXCL12, C10ORF54, NT5E, TNFRSF4, TNFRSF13C, CD40, TMEM173) significantly associated with EPHX4 in HNSCC. Here, TNFRSF13C is linked to head and neck squamous cell carcinoma.