We identified immunostimulators (VTCN1, TGFB1, CDC244, LAG3, PDCD1, TIGIT, IDO1, CD274, ADORA2A, KDR) and immunoinhibitors (TNFSF13, TNFSF4, KLRC1, TNFRSF25, IL2RA, CXCR4, ENTPD1, ULBP1, RAET1E, KLRK1, CD276, TMIGD2, IL6, CXCL12, C10ORF54, NT5E, TNFRSF4, TNFRSF13C, CD40, TMEM173) significantly associated with EPHX4 in HNSCC. The gene discussed is RAET1E; the disease is head and neck squamous cell carcinoma.