GO was used to annotate these 30 genes and KEGG pathway enrichment analysis of these gene showed that cytokine-cytokine receptor interaction, intestinal immune network for IgA production, cell adhesion molecules, natural killer cell mediated cytotoxicity, rheumatoid arthritis, Malaria signaling pathway were associated with EPHX4-mediated tumor-immune microenvironment (Fig. 7B,C). Here, CD79A is linked to rheumatoid arthritis.