We identified immunostimulators (VTCN1, TGFB1, CDC244, LAG3, PDCD1, TIGIT, IDO1, CD274, ADORA2A, KDR) and immunoinhibitors (TNFSF13, TNFSF4, KLRC1, TNFRSF25, IL2RA, CXCR4, ENTPD1, ULBP1, RAET1E, KLRK1, CD276, TMIGD2, IL6, CXCL12, C10ORF54, NT5E, TNFRSF4, TNFRSF13C, CD40, TMEM173) significantly associated with EPHX4 in HNSCC. This evidence concerns the gene KLRC1 and head and neck squamous cell carcinoma.