The pH-responsivePRGD/NLG919 nanosheets demonstrated remarkable singlet oxygen generationand photocytotoxicity in HeLa cells in an acidic tumor microenvironment.When treating HeLa cells with PRGD/NLG919 nanosheets followed by laserirradiation, a more robust adaptive immune response occurred, leadingto a substantial proliferation of CD3+CD8+ Tcells and CD3+CD4+ T cells compared to controlgroups. The gene discussed is CD8A; the disease is neoplasm.