CASP1 and viral infectious disease: To determine how inflammasome activation impacts DENV pathogenesis upon viral infection, we crossed Casp1/11-/- or Nlrp3-/- separately with Ifnar-/- mice to generate Casp1/11-/ -x Ifnar-/- and Nlrp3-/-x Ifnar-/- double-deficient mice and infected them with DENV2 D220.