While it is possible that doxorubicin contributed to the B‐cell depletion noted after 1E4‐cIgGB treatment, a previous study evaluated B‐ and T‐ cell counts in dogs with lymphoma and found no significant changes dogs treated with doxorubicin, but a significant decrease in B‐cells for those receiving CHOP.44 The gene discussed is DDIT3; the disease is lymphoma.