KD of PTBP1 not only induced apoptosis and decreased self renewal in GSC1478 cells, but also induced a neuronal-like morphology and the expression of a neuron marker TUJ1 under a neuronal differentiation culture condition (Figure 9, B and C and Supplemental Figure 7C), which further highlights the association between RBP/AS networks and differentiation programs in glioma. The gene discussed is PTBP1; the disease is glioma.