PKM and cancer: To validate our AS analysis, we selected ten events, including 5 events with known isoform-specific functions (USP5, TPM1, PKM, NED1, and FYN) and 5 events (MPZL1, CARM1, ATG13, FEZ2, and CERS5) whose isoform-specific functions in cancer are less studied but occur in genes implicated in critical cancer-related processes (Figure 2I).