Multivariable survival analyses using a Cox regression model showed that our AS score system is an independent prognostic factor for glioma patient survival after controlling for the 2021 WHO classification, gender, age, IDH mutation, 1p/19q codeletion, and genetic alterations in EGFR and TP53 (Figure 1E and Supplemental Figure 1K). Here, TP53 is linked to central nervous system cancer.