Furthermore, in GOLIM4-deficient cells reconstituted with a GOLIM4 mutant that does not bind to Mn (Supplemental Figure 11M), Mn did not degrade GOLIM4, inhibit secretion, decrease tumor cell viability or migration, or suppress tumor growth or metastasis (Supplemental Figure 11, N–S). The gene discussed is GOLIM4; the disease is neoplasm.