ATP2C1 depletion abrogated Mn-induced GOLIM4 degradation in 3q-amplified cells (Figure 8H), and ectopic coexpression of GOLIM4 and ATP2C1 sensitized a 3q-diploid lung cancer cell line (H23) to Mn treatment (Figure 8, I and J). Here, ATP2C1 is linked to lung carcinoma.