Mn decreased intratumoral GOLIM4 levels irrespective of 3q amplification status but exerted greater proapoptotic and antitumor activity in 3q-amplified than 3q-diploid models, including tumors generated by lung cancer cell lines or lung or pancreatic cancer patient–derived xenografts (PDXs) (Figure 7, A–E, and Supplemental Figure 10, C–E). Here, GOLIM4 is linked to lung cancer.