GOLIM4 and lung carcinoma: Mn decreased intratumoral GOLIM4 levels irrespective of 3q amplification status but exerted greater proapoptotic and antitumor activity in 3q-amplified than 3q-diploid models, including tumors generated by lung cancer cell lines or lung or pancreatic cancer patient–derived xenografts (PDXs) (Figure 7, A–E, and Supplemental Figure 10, C–E).