In this study, we revealed that, of four human pancreatic cancer cell lines, GEM induced senescent features in PANC‐1 and AsPC‐1, leading to growth arrest, increased cell size, enhanced the expression of mRNAs encoding IL‐6/IL‐8 mRNA, and induction of β‐galactosidase (Figure 2). Here, CXCL8 is linked to pancreatic neoplasm.