While measurement of LPS in healthy individuals is difficult due to its low levels and issues with contaminated lab equipment, inhibition of LPS-receptor, the toll-like receptor 4 (TLR4), reduces blood pressure (BP) and inflammatory markers (e.g., IL6, macrophage infiltration to the kidneys) in experimental models of hypertension [17, 18]. This evidence concerns the gene TLR4 and hypertensive disorder.