Chen et al. [35] conducted a GWAS meta-analysis of MAFLD identified by imaging and diagnostic codes across diverse ancestries 17 new loci; the study highlighted new MAFLD-associated variants in or near fat mass and obesity associated (FTO), torsin family 1-member B (TOR1B), cordon-bleu WH2 repeat protein like 1 (COBLL1)/growth factor receptor-bound protein 14 (GRB14), insulin receptor (INSR), and sterol regulatory element-binding transcription factor 1 (SREBF1). Here, INSR is linked to obesity due to melanocortin 4 receptor deficiency.