PCSK7 and iron metabolism disease: Other genes whose mutations are implicated in iron disorders and in MAFLD are ceruloplasmin (CP), serpin family A member 1 (SERPINA1), and proprotein convertase subtilisin/kexin type 7 (PCSK7), which is involved in hepatic inflammation by modulating multiple pathways, such as lipid, iron metabolism, and fibrogenesis [44, 49, 50].