Finally, concerning the role of rare variants, those in ATG7 were identified as modifiers of MAFLD progression in Europeans by enhancing specifically the risk of hepatocellular ballooning (e.g., rs143545741 C>T and rs36117895 T>C) [58], as well as LoF mutations in Telomerase Reverse Transcriptase (TERT) were associated with liver senescence and development of HCC [59]. Here, TERT is linked to hepatocellular carcinoma.