FL/DLBCL has been reported in some studies [11, 12], but to our knowledge, the diagnosis of TdT (terminal deoxynucleotydil transferase) positive “double hit” high grade B cell lymphoma (HGBL) following the treatment of FL/DLBCL has been rarely reported [13]. This evidence concerns the gene DNTT and B-cell non-Hodgkin lymphoma.