In addition, activated and differentiated CD4+ T cells in lymph nodes can present modulated profiles in an inflammatory microenvironment [48, 49] In the current study, we found that blocking IL-33 in vivo significantly decreased the inflammatory cell infiltration in tumour samples and significantly decreased the number of CD4+ T cells, dendritic cells and macrophages (Supplementary Fig. 1). The gene discussed is IL33; the disease is neoplasm.