Papillary RCC may also be a group of tumors with different driving genes, and FHRCC has been misdiagnosed as papillary RCC in many cases before, including the discovery by us and other centers that it may be driven by different genes such as NF2, STED2, and BAP1, and their different evolutionary trees may mean different benefits from tumor reduction. The gene discussed is BAP1; the disease is neoplasm.