Predicted target genes of plant miR159 were enriched in processes such as negative regulation of insulin secretion involved in cellular response to glucose stimulus (PIM3), positive regulation of fatty acid beta-oxidation and glucose metabolism process (IRS1) (Table 3), and pathways such as insulin signalling and type II diabetes mellitus (IRS1) (Table 5). This evidence concerns the gene PIM3 and type 2 diabetes mellitus.