For instance, diffuse gliomas that occur in adults (adult-type gliomas) are given the integrated diagnosis of either astrocytoma, IDH-mutant (that can be grades 2,3 or 4); oligodendroglioma, IDH-mutant (that only can be grade 2 or 3), or IDH wt glioblastoma (G4) and then, the histopathological diagnosis, grade, and other molecular information is provided in the report [3]. The gene discussed is IDH2; the disease is astrocytoma (excluding glioblastoma).