TP53 and acute myeloid leukemia: And some other studies have shown that double minutes (Dms) in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) are associated with micronuclei, MYC or MLL amplification, complex karyotypes, monomeric karyotypes, TP53 deletions, and TP53 mutations [50, 51].