KNG1 and hyperinsulinemic hypoglycemia, familial, 4: The contact activation pathway’s relevance for maintaining hemostatic capacity in vivo has been debated as patients deficient in factor (F) XII, PK (pre-kallikrein), or HK (high molecular weight kininogen) do not typically present with a bleeding phenotype, and Factor XI (FXI) deficiency (hemophilia C), is a mild- to- moderate, tissue-specific bleeding disorder.