For example, exosomal miR-214 released by osteoclasts could inhibit the function of osteoclasts in RA [43], miR-3120 is found to increase the killing effect on virus by affecting the expression of STAT and IRF, promoting the expression of cytokines, such as interleukins and chemokines [44], and miR-615-3p participates in the development and progression of osteoarthritis by promoting inflammatory cytokines including IL-1, IL-6, IL-α, and inhibiting chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) [45]. This evidence concerns the gene TRIM63 and osteoarthritis.