Mutations in CEP290, GUCY2D, and RPE65 are generally more frequent in Caucasian populations [13], while mutations in CRB1, which accounts for 13.6% of LCA cases, are believed to be the leading causative genetic mutation in the Chinese cohort, followed by GUCY2D [14–18]. Here, RPE65 is linked to Leber congenital amaurosis.