C1GALT1 and colonic neoplasm: On the contrary, more studies have shown that elevated expression of C1GALT1 has been observed in a variety of malignant tumors, including esophageal cancer (Wang et al. 2018), gastric cancer (Dong et al. 2021a), colon cancer (Hung et al. 2014a, b), hepatocellular carcinoma (Wu et al. 2013), breast cancer (Chou et al. 2015), prostate cancer (Tzeng et al. 2018), head and neck cancer (Lin et al. 2018), PDAC (Kuo et al. 2021), and ovarian cancer (Chou et al. 2017).