This upregulation of C1GALT1 is associated with the promotion of various malignant cellular phenotypes, such as enhanced cell adhesion, proliferation, migration, invasion, and treatment sensitivity, along with a reduction in immune response and surveillance, ultimately leading to a poor prognosis for cancer patients through multifactorial mechanisms (Xia et al. 2022; Wan et al. 2023). The gene discussed is C1GALT1; the disease is cancer.