They looked at whether previously described eosinophil associated proteins (EAPs) that could be captured by EST (EDN, EPX, MBP-1, Gal-10, CCL26) and periostin, an extracellular matrix protein upregulated in fibrosis, correlated with histologic or endoscopic features of remodeling in 40 pediatric patient with active and inactive EoE. This evidence concerns the gene RNASE2 and eosinophilic esophagitis.