They identified eight T cell subclasses (T1–T8) in the esophageal tissue, including CD8+ clusters T1–6 and, importantly, two CD4+ clusters (T7 and T8) that were enriched in EoE patients with active disease and which represented a population similar to CD4+ Tregs with a regulatory associated phenotype (T7) and a population enriched for CD4+ Th2 cells (T8) producing type 2 cytokines (IL13 and IL5) transcripts. Here, CD4 is linked to eosinophilic esophagitis.