The importance of esophageal fibroblast-epithelial cross-talk in EoE-associated fibrogenesis is further shown in work identifying a potential role for an increase in epithelial expression of TGF-β and of LOX, which can cross-link collagen, in EoE patients with fibrostenotic symptoms and endoscopic signs of fibrosis in response to fibroblast-derived TNF-α [40]. Here, TNF is linked to eosinophilic esophagitis.