Using esophageal biopsies from pediatric and adult subjects across 11 sites in the Consortium of Eosinophilic Gastrointestinal Disease Researchers and in 2 independent replication cohorts, Shoda et al. found that nearly 50% of the patients had fibrostenotic EoE (endoscopic rings, stricture, and/or a history of dilation), and they identified TSPAN12, a member of the EoE transcriptome, as the gene most correlated with fibrostenosis. The gene discussed is TSPAN12; the disease is eosinophilic esophagitis.