PLIN2 and retinitis pigmentosa 1: However, in the case of other adRP RHO mutations, careful individualized dose management of the drug will likely be required to achieve adequate reduction of mutant rhodopsin expression in cases of adRP such that it no longer causes a toxic dominant negative effect while still allowing adequate wild-type RHO expression to allow for normal rod function as complete loss of rhodopsin can cause recessive RP.