Induced pluripotent stem cell (iPSC)-based models have been used to model several retinal degenerations such as RP (Tucker et al., 2013; Giacalone et al., 2019), Usher’s syndrome (Dulla et al., 2021), Leber congenital amaurosis (LCA) (Parfitt et al., 2016; Kruczek et al., 2021), and CRX-associated LCA7 (Chirco et al., 2021). The gene discussed is CRX; the disease is Leber congenital amaurosis.