Increased expression of MCT4 or CD147 correlates with poor prognosis in many cancers (Payen et al., 2020; Xin et al., 2016), and previous work from us and others has established roles for both MCT4 (Kong et al., 2016; Zhu et al., 2014) and CD147 (Grass et al., 2012; Sun and Hemler, 2001) in cancer cell migration and invasion. The gene discussed is BSG; the disease is cancer.