In our laboratory, another NASH model was established using ApoE knockout mice and fed with different diets, HFD and western diet, both groups showed similar results to those described in this study, such as imbalance in glucose metabolism, hepatic steatosis and inflammation, as well as increased collagen deposition in the liver when compared with the group fed the standard diet [6]. Here, APOE is linked to metabolic dysfunction-associated steatohepatitis.