CD4 and atherosclerosis: Because atherosclerosis is marked by a pathogenic CD4+ T cell response,2 and we observed reduced number and activation of APCs, we assessed whether ONX-0914 treatment skewed T helper differentiation away from Th1 cells and toward atheroprotective Tregs, in line with previously described in vitro and in vivo data.12 We did however not observe ONX-0914–mediated induction of CD4+ Tregs by flow cytometry in the spleen, blood, CLN, and MLN (Figure S4A).