IL6 and lipodystrophy: In humans, a homozygous missense mutation in PSMB8 (proteasome subunit beta type-8), encoding for LMP7, causes lipodystrophy, adipose inflammation, and enhanced IL-6 levels.31 Since this phenotype is remarkably similar to the phenotype we observe upon LMP7/2 inhibition in mice, we assessed whether a reduced white adipose tissue (WAT) mass was accompanied by macrophage infiltration in perigonadal (Figure S10A), retroperitoneal (Figure S10B), perirenal (Figure S10C), and mesenteric (Figure S10D) visceral WAT depots after treatment with ONX-0914 for 3 weeks.