60 PP1 is involved in many essential cellular mechanisms and is part of a large interactome with over 200 interactors identified in vertebrates.61 Studies of PPP1R16B showed its high levels of expression in endothelial cells and suggested that PP1 is involved in endothelium stability and permeability.60 The activity of PPP1R16B has been shown to play a role in several diseases, including obesity and diabetes mellitus.60 This evidence concerns the gene PPP1R16B and obesity due to melanocortin 4 receptor deficiency.