HACE1 and carcinoma of esophagus: This study demonstrates that magnolol increases the protein levels of LC3 II, accompanied by increased HACE1 protein levels in both esophageal carcinoma cells and xenograft tumors.HACE1-knockout (KO) cell lines are generated, and the ablation ofHACE1 eliminates the anti-proliferative and autophagy-inducing effects of magnolol on esophageal carcinoma cells.