Furthermore, NFKB2 showed the highest mRNA levels in the CRC specimen in the hepatic metastasis loci, which was higher than that in the CRC specimen in situ and the non‐tumor tissue from the same patient (Figure 1H), suggesting that NFKB2 may be one of the main factors driving CRC metastasis, especially CRC‐hepatic metastasis. This evidence concerns the gene NFKB2 and neoplasm.