In a radiotherapy‐treated NSCLC model, specific induction of apoptosis in senescence‐like cancer‐associated fibroblasts using FOXO4‐DRI (a FOXO4‐p53‐interfering peptide) led to the significant radiosensitivity of NSCLC cells both in vitro and in vivo.303. The gene discussed is FOXO4; the disease is non-small cell lung carcinoma.