On imaging, PSP-SL showed smaller volumes of the motor cortex compared with PSP-RS, consistent with previous descriptions in clinical cohorts24 and with findings suggesting early involvement of posterior frontal regions in the cortical variants of PSP.54 Surprisingly, this was not the case in the superior frontal cortex, where there were comparable volumes across the two variants, despite the difference in the amount of tau pathology. Here, MAPT is linked to supranuclear palsy, progressive, 1.