FN1 and neoplasm: Integrins emerge as critical stiffness-sensors activated by extracellular mechanical forces (Kechagia et al., 2019) and there is ample literature documenting that the increased expression and binding to FN by various integrins, including α5β1, αvβ1, αvβ6, αvβ3, and α9β1, is linked to tumor cell invasion and drug resistance (Koivisto et al., 2000; Barkan and Chambers, 2011; Goodman and Picard, 2012; Gupta et al., 2013; Cooper and Giancotti, 2019; Jang and Beningo, 2019; Li C. et al., 2023; Wu et al., 2023).