Originating mainly from resident tissue fibroblasts under tumor stimuli, CAFs express high levels of α-smooth muscle actin (αSMA) and exert contractile forces and focalized proteolysis, contributing to ECM remodeling and stiffening, and creating tracks that enable the invasion of cancer cells (Kalluri, 2016; Sahai et al., 2020). This evidence concerns the gene ACTA1 and neoplasm.