For example, FN, tenascin-C (TNC), and type I collagen were described to act as pro-metastatic cues (Aguirre-Ghiso et al., 2001; Barkan et al., 2010; Oskarsson et al., 2011), or in patients with breast cancer it was reported that an ECM signature consisting of fibrinogen, elastin, FN, and vitronectin predicts the outcome of the disease (Li S. et al., 2023). Here, FN1 is linked to breast carcinoma.