FN1 and cancer: The glycoprotein fibronectin (FN) is particularly abundant in the microenvironment of malignant tumors (Castellani et al., 1986; Bae et al., 2013; Peng et al., 2022), is the first extracellular matrix (ECM) protein found in specific pre-metastatic niches (Medeiros et al., 2020), is present in the migration tracks used by metastatic cells (Erdogan et al., 2017) and its transcription is induced by hypoxia conditions in certain tumors (Mao et al., 2023).