Significantly, the ablation of Cx43 demonstrates a potential therapeutic avenue, improving renal function in chronic kidney disease induced by hypertension (Haefliger et al., 2006; Alonso et al., 2010; Abed et al., 2014; Yang et al., 2014; Lucero et al., 2022a). The gene discussed is GJA1; the disease is hypertensive disorder.