Lastly, the correlations between the four detection methods (Nabs, Babs, BCRs, and B cell ELISpot) in detecting the peptides or AAV particles were calculated by the Pearson’s score and represented by the “distance” (distance = 1 – the Pearson’s score), and BCR detection exhibited the closest proximity to Nab detection in patients with hemophilia (Figure 3E). Here, BCR is linked to hemophilia.