High-normal circulating PRL levels increase breast cancer risk in both pre- and post-menopausal women(Tworoger, Eliassen, Rosner, Sluss, & Hankinson, 2004; Tworoger & Hankinson, 2006; M. Wang, Wu, Chai, Zhang, & Jiang, 2016). The gene discussed is PRL; the disease is breast carcinoma.