TPX2 and cancer: Targeting Protein for Xklp2 (TPX2) is a RanGTP-regulated importin cargo that is overexpressed in many aggressive human cancers and is associated with chromosomal instability(Asteriti et al., 2010; Carter et al., 2006; Castro et al., 2007; Hu et al., 2012; Neumayer et al., 2014).