In addition to TTNtvs, a long list of missense variants in titin have also been identified in association with DCM, as well as peripartum cardiomyopathy (PPCM) (Merlo et al., 2013; Pugh et al., 2014; van Spaendonck-Zwarts et al., 2014; Begay et al., 2015; Akinrinade et al., 2019); however, evidence indicating a causal association between these variants and disease has been largely lacking. The gene discussed is TTN; the disease is familial dilated cardiomyopathy.