As shown in Figure 5E, the DEGs that were down-regulated in DM compared to NM were primarily related to the ribosome (about 23 DEGs, including RPL37A and RPS11), Alzheimer’s disease (about 19 DEGs, including APC2 and COX8A), and non-alcoholic fatty liver disease (about 11 DEGs, such as SNCA and COX8A). The gene discussed is COX8A; the disease is early-onset autosomal dominant Alzheimer disease.