TNNC1 and early-onset autosomal dominant Alzheimer disease: The down-regulated DEGs in DM versus NN (Figure 5C) were primarily focused on ribosome (approximately 80 DEGs, including RPL37 and RPS11), Alzheimer’s disease (about 86 DEGs), and cardiac muscle contraction (about 22 DEGs, such as UQCRQ and TNNC1).