COX8A and early-onset autosomal dominant Alzheimer disease: As shown in Figure 5, the down-regulated DEGs in NM versus NN (Figure 5A) were primarily focused on ribosome (about 26 DEGs, including RPL37A and RPL35), Alzheimer’s disease (about 20 DEGs, including SNCA and COX8A), and retrograde endocannabinoid signaling (about 6 DEGs, such as NDUFA1 and GNG5).