This level is about 38.5 folds of that reported by Somuncu et al., who showed that patients with MI, who had MMP-9 plasma levels above 12.92 ng/mL at the time of hospital admission, had 3.5-fold higher odds for cardiovascular mortality and increased risk for advanced heart failure compared to patients with lower MMP-9 level (8). The gene discussed is MMP9; the disease is advanced heart failure.