We applied ROC models to calculate the AUC, accuracy, specificity and sensitivity of single biomarker of age, ApoE4 genotype and rGSK-3β for diagnosing incident MCI in T2DM patients (Figure 5) Among the three biomarkers, age exhibited a maximum AUC of 64% and an accuracy of 80.6% (Table 3). Here, APOE is linked to type 2 diabetes mellitus.