GSK3B and Mental deterioration: Our results indicated that age (OR 1.09, 95% CI 1.04, 1.14), ApoE4 genotype (OR 2.68, 95% CI 1.11, 6.47), platelet GSK-3β activity (OR 1.87, 95% CI 1.05, 3.34) are independently associated with cognitive decline at follow-up.