Although the association between E and MS has been conflicting among men and women (29, 36, 37, 42, 43), the FEI was positively associated with MS and high CRP even after adjusting for TT, E, and SHBG concentrations indicating the usefulness of FEI in the context of MS and CRP-related diseases. The gene discussed is SHBG; the disease is myeloid sarcoma.