However, a longitudinal analysis of two cohorts of idiopathic PD patients and a cohort of LRRK2 G2019S mutation carriers identified a strong influence of Horvath clock acceleration on incident PD risk, revealing that a 5-year increase in DNAm age acceleration was associated with a 6-year earlier PD onset (8), in contrast with the evidence reported here and elsewhere (10). This evidence concerns the gene LRRK2 and Parkinson disease.