Of the identified genes, 1 (GPC2) was associated with doctor-diagnosed COPD, 10 (TESK2, AKR1A1, LMCD1, ERBB3, PSMA4, MAST2, MMP15, MRC2, BMP4, and LTK) with FEV1/FVC <0.7, and 11 (APH1A, CHI3L2, PTK7, RASGRP3, HSP90AA1, TESK2, ADAM33, COL15A1, LINGO1, LTBR, and SULT1A1) with FEV1 in protein SMR results, without contradicting the expression SMR results. Here, CHI3L2 is linked to chronic obstructive pulmonary disease.