Of the identified genes, 1 (GPC2) was associated with doctor-diagnosed COPD, 10 (TESK2, AKR1A1, LMCD1, ERBB3, PSMA4, MAST2, MMP15, MRC2, BMP4, and LTK) with FEV1/FVC <0.7, and 11 (APH1A, CHI3L2, PTK7, RASGRP3, HSP90AA1, TESK2, ADAM33, COL15A1, LINGO1, LTBR, and SULT1A1) with FEV1 in protein SMR results, without contradicting the expression SMR results. The gene discussed is TESK2; the disease is chronic obstructive pulmonary disease.