In the early stage of myocardial infarction, the massive infiltration of inflammatory cells will promote the activation of MMPs, leading to the massive degradation of the extracellular matrix such as myocardial collagen, fibronectin, and laminin, resulting in the loss of myocardial mesenchymal skeleton support and protection, and the disruption of the tissue structure, promoting disproportionate thinning and expansion of the infarcted areas and ultimately leading to CR (12, 13). This evidence concerns the gene FN1 and myocardial infarction.