MEFV and hyperinsulinemic hypoglycemia, familial, 4: Pyrin plays a role in inflammatory diseases such as Familial Mediterranean Fever (FMF), pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND), and mevalonate kinase deficiency (De Torre-Minguela et al., 2017; Schnappauf et al., 2019; Alehashemi and Goldbach-Mansky, 2020).