In the IBD dataset, we found that the VCAM1, SERPING1, C3 and CLU genes were positively correlated with B cells naive, macrophages M0, activated dendritic cells, neutrophils and T cells follicular helper; VCAM1, SERPING1 and CLU showed negative correlation with resting dendritic cells, eosinophils, M2 macrophages, monocytes, CD4 memory resting T cells and T cells regulatory (Tregs); CD55 was positively correlated with M0 macrophages, M1 macrophages and neutrophils and negatively correlated with resting dendritic cells, eosinophils and monocytes (Figure 7G) by correlation analysis. The gene discussed is CLU; the disease is inflammatory bowel disease.