Changes in macrophage homeostasis can affect IBD, such as sphingosine 1-phosphate receptor 2 (S1PR2) and its downstream G protein RhoA/Rho kinase 1 (ROCK1) signaling pathway can aggravate IBD by regulating polarization to M1-like macrophages, in addition, Yes-related protein (YAP) can inhibit M2-like macrophages and promote the production of IL-6 in M1-like macrophages to regulate the pathological process of IBD (88, 89). Here, RHOA is linked to inflammatory bowel disease.