IL6 and autoimmune hepatitis: A potential therapeutic target for AIH is Receptor-interacting protein kinase 3 (RIP3), which can contribute to macrophage activation in AIH and promote IL-6 production, in addition, enhancer of zeste homolog 2 (EZH2) -mediated H3K27me3 may also influence the progression of AIH by modulating the polarization of macrophages, EZH2 is also promising as a therapeutic target (79, 80).