HIF1A and ulcerative colitis: Another example is Tiliroside, which promotes the proteasomal degradation of HIF-1α and down-regulates HIF-1α-dependent glycolytic enzyme mRNA expression in macrophages, thereby regulating M1/M2 macrophage polarization (105).Wu-Mei-Wan, Dioscin, and Shaoyao have all been reported to relieve ulcerative colitis by suppressing M1-like macrophage polarization by different study teams (106–109).