Numerous translational research initiatives have explored the role of different molecular markers such as PD-L1 (1, 7, 8), tumor mutational burden (TMB) (9–12), PBRM1 loss-of-function mutations (13), alterations in DNA damage response and repair genes (13), gene expression signatures (13), and T-cell receptor clonality in the tumor microenvironment (14). This evidence concerns the gene CD274 and neoplasm.