TNFRSF12A, alternatively named FN14, belongs to the TNF/TNFR superfamily and has been reported to be involved in the initiation and progression of multiple tumor types, including glioma, pancreatic, breast, non-small-cell lung cancer, and colorectal cancer [[28], [29], [30]]. This evidence concerns the gene TNFRSF1A and colorectal cancer.