While TLR9 may recognize self-DNA for anti-inflammatory effects during infection and for homeostasis (7, 8), TLR9 stimulation for some reason causes the production of antinuclear antibodies in the pathology of autoimmune diseases, such as systemic lupus erythematosus (SLE) (9–13). Here, TLR9 is linked to systemic lupus erythematosus.